Ruination is the process of being ruined — of a life, a plan, a building, a reputation falling to pieces — or the thing that causes that fall. Drink was his ruination means drink is what wrecked him. The ruination of the old mill can mean the wrecking of it. Though actually, people often use it with a wink. These children will be the ruination of me is a parent joking that the kids are wearing them out, not announcing a real disaster. The humorous, slightly theatrical use is very common; the dead-serious use is rarer and sounds a bit old. Ruin as a verb or noun is the everyday word; ruination adds weight, or mock-weight.

毀滅、敗壞（常帶點誇張或開玩笑）